|
KMID : 0191119970120050427
|
|
Journal of Korean Medical Science
1997 Volume.12 No. 5 p.427 ~ p.432
|
|
|
Relationship of transforming growth factor beta 1 to angiogenesis in gastric carcinoma
|
|
Choi YH
Choi KC/Park YE
|
|
|
Abstract
|
|
|
Transforming growth factor-beta (TGF-beta) comprises a group of multifunctional regulatory proteins, whose
effects include angiogenesis. The expression of TGF-beta 1 in gastric carcinomas (70 cases) has been
determined and related to pathological features and microvessel count by immunohistochemical staining
for TGF-beta 1 and Factor VIII related antigen. Prominent reactivity for TGF-beta 1 was associated with
the depth of invasion (r = 0.2; p < 0.05) and increased microvessel count (r = 0.5; p < 0.05). Also, the
microvessel count had a significant correlation with invasiveness (r = 0.34; p < 0.05) and lymph node
metastasis (r = 0.28; p < 0.05). These findings indicate that TGF-beta 1 may have a role in tumor invasion
and angiogenesis.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|